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William D Figg Selected Research

Poly(ADP-ribose) Polymerase Inhibitors

10/2023PARP inhibitors: A review of the pharmacology, pharmacokinetics, and pharmacogenetics.
1/2022PARP inhibitors on the move in prostate cancer: spotlight on Niraparib & update on PARP inhibitor combination trials.
1/2021Resistance to second-generation androgen receptor antagonists in prostate cancer.
1/2021A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models.
1/2021PARP Inhibitors and Prostate Cancer: To Infinity and Beyond BRCA.
1/2019A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1-3 inhibitor, cediranib, in recurrent women's cancers with biomarker analyses.
7/2017Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study.
7/2008Secondary BRCA1 and BRCA2 alterations and acquired chemoresistance.

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William D Figg Research Topics

Disease

238Neoplasms (Cancer)
01/2024 - 01/2002
179Prostatic Neoplasms (Prostate Cancer)
01/2024 - 01/2002
24Neoplasm Metastasis (Metastasis)
01/2023 - 01/2002
23Disease Progression
10/2023 - 05/2005
21Breast Neoplasms (Breast Cancer)
01/2023 - 02/2003
17Hypoxia (Hypoxemia)
11/2023 - 09/2003
16Carcinoma (Carcinomatosis)
01/2024 - 10/2003
16Multiple Myeloma
11/2021 - 11/2004
14Neutropenia
01/2023 - 05/2002
10Diarrhea
01/2021 - 02/2003
9Renal Cell Carcinoma (Grawitz Tumor)
11/2023 - 07/2004
9Fatigue
01/2021 - 05/2002
7Glioma (Gliomas)
12/2023 - 06/2003
7Thrombocytopenia (Thrombopenia)
11/2021 - 05/2005
7Carcinogenesis
01/2018 - 06/2002
6Brain Neoplasms (Brain Tumor)
12/2023 - 06/2003
6Colorectal Neoplasms (Colorectal Cancer)
03/2023 - 11/2004
6Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
04/2016 - 02/2009
6Lymphoma (Lymphomas)
11/2014 - 06/2005
5Hematologic Neoplasms (Hematological Malignancy)
01/2022 - 06/2007
5Infections
12/2021 - 07/2010
5Ovarian Neoplasms (Ovarian Cancer)
06/2021 - 08/2008
5Lung Neoplasms (Lung Cancer)
11/2020 - 04/2002
5Melanoma (Melanoma, Malignant)
11/2020 - 06/2007
5Pain (Aches)
10/2020 - 02/2003
5Hypertension (High Blood Pressure)
07/2017 - 02/2009
5T-Cell Lymphoma (Lymphoma, T Cell)
08/2013 - 02/2009
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2020 - 09/2007

Drug/Important Bio-Agent (IBA)

59AndrogensIBA
09/2023 - 05/2002
32Thalidomide (Thalomid)FDA Link
01/2018 - 02/2002
31Docetaxel (Taxotere)FDA Link
01/2021 - 01/2003
30Biomarkers (Surrogate Marker)IBA
01/2024 - 05/2002
29Androgen Receptors (Androgen Receptor)IBA
01/2021 - 01/2002
21Proteins (Proteins, Gene)FDA Link
01/2023 - 04/2002
20Hormones (Hormone)IBA
01/2022 - 05/2002
18Lenalidomide (CC 5013)FDA Link
01/2023 - 05/2002
18Histone Deacetylase InhibitorsIBA
01/2020 - 03/2002
18Prostate-Specific Antigen (Semenogelase)IBA
01/2020 - 09/2002
17Paclitaxel (Taxol)FDA LinkGeneric
06/2021 - 04/2002
15Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2019 - 01/2002
14VA 061 (VA061)IBA
12/2008 - 01/2003
13olaparibIBA
10/2023 - 06/2014
13Sorafenib (BAY 43-9006)FDA Link
11/2021 - 10/2006
13Angiogenesis InhibitorsIBA
10/2014 - 05/2002
12EnzymesIBA
10/2023 - 03/2002
12Finasteride (Propecia)FDA LinkGeneric
01/2022 - 04/2008
12Testosterone (Sustanon)FDA Link
01/2017 - 03/2006
12romidepsin (FK228)FDA Link
11/2016 - 03/2002
12Bevacizumab (Avastin)FDA Link
10/2016 - 08/2008
11DNA (Deoxyribonucleic Acid)IBA
10/2023 - 01/2002
11alvocidib (flavopiridol)IBA
01/2019 - 05/2002
10Transcription Factors (Transcription Factor)IBA
09/2017 - 09/2003
9Prednisone (Sone)FDA LinkGeneric
01/2021 - 02/2009
9entinostat (MS 275)IBA
01/2020 - 05/2004
8Immune Checkpoint InhibitorsIBA
01/2024 - 01/2015
8Antineoplastic Agents (Antineoplastics)IBA
10/2023 - 05/2002
8Poly(ADP-ribose) Polymerase InhibitorsIBA
10/2023 - 07/2008
7enzalutamideIBA
10/2023 - 06/2015
7Interleukin-15 (Interleukin 15)IBA
11/2021 - 05/2011
7Dexamethasone (Maxidex)FDA LinkGeneric
11/2021 - 01/2017
7belinostatIBA
01/2018 - 11/2014
6Temozolomide (Temodar)FDA LinkGeneric
01/2023 - 10/2014
6SteroidsIBA
01/2022 - 12/2008
6carfilzomibIBA
11/2021 - 01/2017
6CytochromesIBA
01/2020 - 10/2005
6Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
01/2020 - 08/2007
6PlatinumIBA
01/2020 - 07/2008
6Estrogens (Estrogen)FDA Link
01/2018 - 12/2003
6Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
06/2017 - 10/2005
6DepsipeptidesIBA
06/2011 - 03/2002
5Cisplatin (Platino)FDA LinkGeneric
01/2024 - 11/2014
5Diphosphonates (Bisphosphonates)IBA
12/2021 - 12/2002
5Tyrosine Kinase InhibitorsIBA
11/2021 - 08/2004
5abirateroneIBA
01/2021 - 12/2014
5Cyclophosphamide (Cytoxan)FDA LinkGeneric
12/2019 - 12/2004
5Carboplatin (JM8)FDA LinkGeneric
04/2019 - 06/2014
5carotuximabIBA
08/2017 - 09/2012
5EndoglinIBA
08/2017 - 09/2012
5Member 1 Subfamily B ATP Binding Cassette TransporterIBA
02/2011 - 07/2004
5Matrix Metalloproteinases (MMPs)IBA
06/2004 - 01/2002
4rucaparibIBA
01/2024 - 01/2021
4tremelimumabIBA
01/2024 - 01/2017
4durvalumabIBA
01/2024 - 07/2017
4Immunotoxins (Immunotoxin)IBA
01/2024 - 01/2020
4Oxygen (Dioxygen)IBA
11/2023 - 11/2005
4Monoclonal AntibodiesIBA
04/2023 - 10/2014
4CamptothecinIBA
01/2022 - 03/2020
4cabozantinibIBA
01/2022 - 01/2020
4IT-101IBA
01/2022 - 03/2020
4taxaneIBA
06/2021 - 04/2002
4pomalidomideIBA
01/2021 - 06/2007
4Immunomodulating AgentsIBA
01/2021 - 06/2007
4ProdrugsIBA
01/2021 - 12/2017
4CytokinesIBA
01/2020 - 01/2015

Therapy/Procedure

107Therapeutics
09/2023 - 04/2002
53Castration
01/2024 - 09/2007
32Drug Therapy (Chemotherapy)
01/2023 - 01/2003
11Radiotherapy
01/2023 - 02/2004
6Immunotherapy
10/2023 - 01/2015
4Precision Medicine
04/2021 - 01/2017